http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/ Meddling with things mankind is not meant to understand. Also, pictures of my kids Sat, 25 Jun 2011 18:45:54 +0000 hourly 1 http://wordpress.org/?v=3.3 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-61942 Xenobio Fri, 01 Oct 2010 08:25:08 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-61942 It's a bit extreme to call chemotherapy and radiotherapy cargo-cult medicine. Even if it only kills a portion of the tumour cells, that's still a substantially smaller load of cancer cells remaining for the immune system to clear, and given that tumour cells multiply fast, that's not a mathematically trivial thing. It’s a bit extreme to call chemotherapy and radiotherapy cargo-cult medicine. Even if it only kills a portion of the tumour cells, that’s still a substantially smaller load of cancer cells remaining for the immune system to clear, and given that tumour cells multiply fast, that’s not a mathematically trivial thing.

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-43374 DAMPs and PAMPs: The enemy within | Mystery Rays from Outer Space Wed, 24 Mar 2010 10:17:24 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-43374 [...] talked before about these two forms of problem detection. To summarize and grossly oversimplify some of the history: Charlie Janeway predicted the first [...] [...] talked before about these two forms of problem detection. To summarize and grossly oversimplify some of the history: Charlie Janeway predicted the first [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-43217 Stories [1] – Polly Matzinger, the Bunny & the Dog « Laika’s MedLibLog Mon, 22 Mar 2010 02:05:06 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-43217 [...] She emphasize for instance that tumors are often not seen as dangerous and therefore not attacked by the immune system, until they outgrow their blood supply, undergo chemotherapy, or otherwise are harmed. Then the damaged tumor cells release endogenous danger signals that help trigger the adaptive response. (see this excellent blog post at Mystery Rays from Outer Space for more detailed discussion). [...] [...] She emphasize for instance that tumors are often not seen as dangerous and therefore not attacked by the immune system, until they outgrow their blood supply, undergo chemotherapy, or otherwise are harmed. Then the damaged tumor cells release endogenous danger signals that help trigger the adaptive response. (see this excellent blog post at Mystery Rays from Outer Space for more detailed discussion). [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-42401 Blowing out the candles | Mystery Rays from Outer Space Sat, 06 Mar 2010 21:36:31 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-42401 [...] something abnormal going on, and the immune system detects uncoordinated cell death as danger and responds with inflammation — but the usual form of cell death is highly coordinated, with the cell carefully tidying up [...] [...] something abnormal going on, and the immune system detects uncoordinated cell death as danger and responds with inflammation — but the usual form of cell death is highly coordinated, with the cell carefully tidying up [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-41494 A scarifying story | Mystery Rays from Outer Space Wed, 10 Feb 2010 11:18:21 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-41494 [...] the fact that the skin is damaged in the process evokes Polly Matzinger’s “danger” concept of immune [...] [...] the fact that the skin is damaged in the process evokes Polly Matzinger’s “danger” concept of immune [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-37456 Why a vaccine failed, and maybe a fix | Mystery Rays from Outer Space Mon, 07 Dec 2009 12:32:05 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-37456 [...] problem; rather, it’s the lack of adjuvant stimulation. Specifically, they say, you need to stimulate innate immunity via toll-like receptors (TLRs). Unless you do this, B cells don’t become completely [...] [...] problem; rather, it’s the lack of adjuvant stimulation. Specifically, they say, you need to stimulate innate immunity via toll-like receptors (TLRs). Unless you do this, B cells don’t become completely [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-29001 Science letter roundup | Mystery Rays from Outer Space Fri, 24 Jul 2009 16:28:16 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-29001 [...] Taking advantage of the dirty little secrets [...] [...] Taking advantage of the dirty little secrets [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-5400 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » Alum, take 2: A better answer Wed, 28 May 2008 13:29:39 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-5400 [...] We’ve known for quite a while now how adjuvants work. Adjuvants (the components of vaccines that cause an immune response to start up, but that are not themselves the target of the immune response) trigger the parts of the innate immune system that normally identify microbial patterns, so that the immune system becomes aware that there’s a dangerous situation on its hands. (I have a much longer explanation here.) [...] [...] We’ve known for quite a while now how adjuvants work. Adjuvants (the components of vaccines that cause an immune response to start up, but that are not themselves the target of the immune response) trigger the parts of the innate immune system that normally identify microbial patterns, so that the immune system becomes aware that there’s a dangerous situation on its hands. (I have a much longer explanation here.) [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-3461 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » The weak conquers the strong Mon, 05 May 2008 03:26:18 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-3461 [...] the strong By iayork I’ve talked several times about Charlie Janeway’s “dirty little secrets“, and the insights into fundamental immunity that arose from the concept. I’ve also [...] [...] the strong By iayork I’ve talked several times about Charlie Janeway’s “dirty little secrets“, and the insights into fundamental immunity that arose from the concept. I’ve also [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-2075 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » How does alum adjuvant work? Thu, 17 Apr 2008 02:14:05 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-2075 [...] theory of adjuvants3 which has for the most part proven triumphantly true. (I talked about it here.) He suggested that the immune system normally initiates a response when it recognizes conserved [...] [...] theory of adjuvants3 which has for the most part proven triumphantly true. (I talked about it here.) He suggested that the immune system normally initiates a response when it recognizes conserved [...]

]]>