http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/ Meddling with things mankind is not meant to understand. Also, pictures of my kids Tue, 16 Mar 2010 19:05:46 +0000 http://wordpress.org/?v=2.9.2 hourly 1 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-42401 Blowing out the candles | Mystery Rays from Outer Space Sat, 06 Mar 2010 21:36:31 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-42401 [...] something abnormal going on, and the immune system detects uncoordinated cell death as danger and responds with inflammation — but the usual form of cell death is highly coordinated, with the cell carefully tidying up [...] [...] something abnormal going on, and the immune system detects uncoordinated cell death as danger and responds with inflammation — but the usual form of cell death is highly coordinated, with the cell carefully tidying up [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-41494 A scarifying story | Mystery Rays from Outer Space Wed, 10 Feb 2010 11:18:21 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-41494 [...] the fact that the skin is damaged in the process evokes Polly Matzinger’s “danger” concept of immune [...] [...] the fact that the skin is damaged in the process evokes Polly Matzinger’s “danger” concept of immune [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-37456 Why a vaccine failed, and maybe a fix | Mystery Rays from Outer Space Mon, 07 Dec 2009 12:32:05 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-37456 [...] problem; rather, it’s the lack of adjuvant stimulation. Specifically, they say, you need to stimulate innate immunity via toll-like receptors (TLRs). Unless you do this, B cells don’t become completely [...] [...] problem; rather, it’s the lack of adjuvant stimulation. Specifically, they say, you need to stimulate innate immunity via toll-like receptors (TLRs). Unless you do this, B cells don’t become completely [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-29001 Science letter roundup | Mystery Rays from Outer Space Fri, 24 Jul 2009 16:28:16 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-29001 [...] Taking advantage of the dirty little secrets [...] [...] Taking advantage of the dirty little secrets [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-5400 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » Alum, take 2: A better answer Wed, 28 May 2008 13:29:39 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-5400 [...] We’ve known for quite a while now how adjuvants work. Adjuvants (the components of vaccines that cause an immune response to start up, but that are not themselves the target of the immune response) trigger the parts of the innate immune system that normally identify microbial patterns, so that the immune system becomes aware that there’s a dangerous situation on its hands. (I have a much longer explanation here.) [...] [...] We’ve known for quite a while now how adjuvants work. Adjuvants (the components of vaccines that cause an immune response to start up, but that are not themselves the target of the immune response) trigger the parts of the innate immune system that normally identify microbial patterns, so that the immune system becomes aware that there’s a dangerous situation on its hands. (I have a much longer explanation here.) [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-3461 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » The weak conquers the strong Mon, 05 May 2008 03:26:18 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-3461 [...] the strong By iayork I’ve talked several times about Charlie Janeway’s “dirty little secrets“, and the insights into fundamental immunity that arose from the concept. I’ve also [...] [...] the strong By iayork I’ve talked several times about Charlie Janeway’s “dirty little secrets“, and the insights into fundamental immunity that arose from the concept. I’ve also [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-2075 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » How does alum adjuvant work? Thu, 17 Apr 2008 02:14:05 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-2075 [...] theory of adjuvants3 which has for the most part proven triumphantly true. (I talked about it here.) He suggested that the immune system normally initiates a response when it recognizes conserved [...] [...] theory of adjuvants3 which has for the most part proven triumphantly true. (I talked about it here.) He suggested that the immune system normally initiates a response when it recognizes conserved [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-1325 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » Autoimmune hypotheses Mon, 04 Feb 2008 12:08:48 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-1325 [...] self epitopes; the self epitopes are usually ignored because they are not seen in an inflammatory (“danger”) context; but the pathogen epitope is seen in such a context and drives the activation and [...] [...] self epitopes; the self epitopes are usually ignored because they are not seen in an inflammatory (“danger”) context; but the pathogen epitope is seen in such a context and drives the activation and [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-1001 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » Oncolytic viruses and immune clearance Thu, 10 Jan 2008 12:17:57 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-1001 [...] just as described in the paper by Apetoh et al13 that I talked about here. The authors suggest that because the cancer metastases are being killed in the lymph nodes, rather [...] [...] just as described in the paper by Apetoh et al13 that I talked about here. The authors suggest that because the cancer metastases are being killed in the lymph nodes, rather [...]

]]> http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/comment-page-1/#comment-835 Mystery Rays from Outer Space - Meddling with things mankind is not meant to understand. Also, pictures of my kids » The Twelve Days of Mystery Rays Mon, 31 Dec 2007 18:21:30 +0000 http://www.iayork.com/MysteryRays/2007/09/10/taking-advantage-of-the-dirty-little-secrets/#comment-835 [...] The Twelve Days of Mystery Rays By iayork I’ve saved 229 papers from 2007 in my References database. Here are some of the ones I was especially struck by this year. This doesn’t necessarily mean “most significant”, or “most dramatic”, or anything other than “I thought they were cool”. Twelve papers — one per month1 — in alphabetical order so I don’t have to decide between them: 1. Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A. et al. (2007). Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med, 13, 1050 - 1059. Suggests that the real reason chemotherapy works is not that it kills the tumor cells, but rather that the tumor cells are rendered capable of priming the adaptive immune system; it’s the immune system that actually does the work of killing off the tumor. I talked about this paper here. [...] [...] The Twelve Days of Mystery Rays By iayork I’ve saved 229 papers from 2007 in my References database. Here are some of the ones I was especially struck by this year. This doesn’t necessarily mean “most significant”, or “most dramatic”, or anything other than “I thought they were cool”. Twelve papers — one per month1 — in alphabetical order so I don’t have to decide between them: 1. Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A. et al. (2007). Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med, 13, 1050 – 1059. Suggests that the real reason chemotherapy works is not that it kills the tumor cells, but rather that the tumor cells are rendered capable of priming the adaptive immune system; it’s the immune system that actually does the work of killing off the tumor. I talked about this paper here. [...]

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