Comments on: Proteasome subunit-dependent signaling in T cells? http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/ Meddling with things mankind is not meant to understand. Also, pictures of my kids Sat, 25 Jun 2011 18:45:54 +0000 hourly 1 http://wordpress.org/?v=3.3 By: Gaby http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/comment-page-1/#comment-198296 Gaby Wed, 01 Jun 2011 12:45:34 +0000 http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/#comment-198296 It took me a little while to absorb the idea presented in this article BUT yes, it is very intriguing indeed! I would need to read the references though to better grasp the idea discussed. It took me a little while to absorb the idea presented in this article BUT yes, it is very intriguing indeed! I would need to read the references though to better grasp the idea discussed.

]]> By: iayork http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/comment-page-1/#comment-1335 iayork Tue, 05 Feb 2008 02:49:01 +0000 http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/#comment-1335 Nice to hear from you again, Kay. Hope you had a good holiday. Yeah, it's really intriguing idea. It took me a little while to warm up to it, but of course the proteasome already has well-defined roles in cell signaling, so a mechanism comes pretty easily. The thymus-specific subunit is a main reason I like the idea now, because as you know I wasn't very happy with the proposed model at the time, and I really think for the observed effects signaling is a better fit in some ways. Nice to hear from you again, Kay. Hope you had a good holiday.

Yeah, it’s really intriguing idea. It took me a little while to warm up to it, but of course the proteasome already has well-defined roles in cell signaling, so a mechanism comes pretty easily. The thymus-specific subunit is a main reason I like the idea now, because as you know I wasn’t very happy with the proposed model at the time, and I really think for the observed effects signaling is a better fit in some ways.

]]> By: Suicyte http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/comment-page-1/#comment-1329 Suicyte Mon, 04 Feb 2008 20:22:07 +0000 http://www.iayork.com/MysteryRays/2008/01/23/proteasome-subunit-dependent-signaling-in-t-cells/#comment-1329 Great Article! I had totally missed these papers, but a non-MHC presentation role for the immunoproteasome is an intriguing idea. Great Article! I had totally missed these papers, but a non-MHC presentation role for the immunoproteasome is an intriguing idea.

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