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	<title>Comments on: Increasing virus virulence</title>
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	<link>http://www.iayork.com/MysteryRays/2008/03/24/increasing-virus-virulence/</link>
	<description>Meddling with things mankind is not meant to understand.  Also, pictures of my kids</description>
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		<title>By: Swine flu, virulence, and jumping viruses &#124; Mystery Rays from Outer Space</title>
		<link>http://www.iayork.com/MysteryRays/2008/03/24/increasing-virus-virulence/comment-page-1/#comment-22513</link>
		<dc:creator>Swine flu, virulence, and jumping viruses &#124; Mystery Rays from Outer Space</dc:creator>
		<pubDate>Thu, 30 Apr 2009 15:11:12 +0000</pubDate>
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		<description>[...] Increasing virus virulence [...]</description>
		<content:encoded><![CDATA[<p>[...] Increasing virus virulence [...]</p>
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		<title>By: Evolution of a vaccine &#124; Mystery Rays from Outer Space</title>
		<link>http://www.iayork.com/MysteryRays/2008/03/24/increasing-virus-virulence/comment-page-1/#comment-8728</link>
		<dc:creator>Evolution of a vaccine &#124; Mystery Rays from Outer Space</dc:creator>
		<pubDate>Wed, 01 Oct 2008 01:09:12 +0000</pubDate>
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		<description>[...] while ago, I talked about the influence of vaccination on Marek&#8217;s Disease Virus. Marek&#8217;s Disease Virus (MDV) is a [...]</description>
		<content:encoded><![CDATA[<p>[...] while ago, I talked about the influence of vaccination on Marek&#8217;s Disease Virus. Marek&#8217;s Disease Virus (MDV) is a [...]</p>
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		<title>By: iayork</title>
		<link>http://www.iayork.com/MysteryRays/2008/03/24/increasing-virus-virulence/comment-page-1/#comment-1821</link>
		<dc:creator>iayork</dc:creator>
		<pubDate>Mon, 24 Mar 2008 15:23:48 +0000</pubDate>
		<guid isPermaLink="false">http://www.iayork.com/MysteryRays/2008/03/24/increasing-virus-virulence/#comment-1821</guid>
		<description>&lt;em&gt;I donâ€™t think Varivax (the anti-chicken pox vaccine) prevents infection&lt;/em&gt;

Are you sure about that?  I thought it does prevent infection with wild-type virus.  In general herpesviruses don&#039;t superinfect well (though it does happen) and since the vaccine virus establishes its own persistent infection I&#039;d expect that superinfection with wild-type virus would be rare.   If I&#039;m interpreting a number of papers correctly, this is correct -- superinfection with wild-type virus does occur but it&#039;s unusual, a few percent, and associated with reduced disease -- but almost everything I find does look more at disease than evidence of infection.  

Testing for superinfection would probably be very difficult, because you can&#039;t use the usual seroconversion measures; you&#039;d have to actually sequence out virus and confirm that it&#039;s wild-type and not vaccine strain.  I believe that it&#039;s this technical difficulty that&#039;s led to the FDA definition of preventing disease rather than infection.</description>
		<content:encoded><![CDATA[<p><em>I donâ€™t think Varivax (the anti-chicken pox vaccine) prevents infection</em></p>
<p>Are you sure about that?  I thought it does prevent infection with wild-type virus.  In general herpesviruses don&#8217;t superinfect well (though it does happen) and since the vaccine virus establishes its own persistent infection I&#8217;d expect that superinfection with wild-type virus would be rare.   If I&#8217;m interpreting a number of papers correctly, this is correct &#8212; superinfection with wild-type virus does occur but it&#8217;s unusual, a few percent, and associated with reduced disease &#8212; but almost everything I find does look more at disease than evidence of infection.  </p>
<p>Testing for superinfection would probably be very difficult, because you can&#8217;t use the usual seroconversion measures; you&#8217;d have to actually sequence out virus and confirm that it&#8217;s wild-type and not vaccine strain.  I believe that it&#8217;s this technical difficulty that&#8217;s led to the FDA definition of preventing disease rather than infection.</p>
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		<title>By: David Loeb</title>
		<link>http://www.iayork.com/MysteryRays/2008/03/24/increasing-virus-virulence/comment-page-1/#comment-1820</link>
		<dc:creator>David Loeb</dc:creator>
		<pubDate>Mon, 24 Mar 2008 14:18:35 +0000</pubDate>
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		<description>I don&#039;t think Varivax (the anti-chicken pox vaccine) prevents infection.  Its FDA approval is based on a reduction of &lt;b&gt;serious&lt;/b&gt; infections.  Not the overall number of infections.  Vaccinated kids still get chicken pox, but they get far fewer lesions and are far less systemically ill.  I had never thought about the issue you raise here before (possibly because I&#039;m not a virologist or an immunologist)... but this actually raises a red flag around universal vaccination against varicella.</description>
		<content:encoded><![CDATA[<p>I don&#8217;t think Varivax (the anti-chicken pox vaccine) prevents infection.  Its FDA approval is based on a reduction of <b>serious</b> infections.  Not the overall number of infections.  Vaccinated kids still get chicken pox, but they get far fewer lesions and are far less systemically ill.  I had never thought about the issue you raise here before (possibly because I&#8217;m not a virologist or an immunologist)&#8230; but this actually raises a red flag around universal vaccination against varicella.</p>
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