Comments on: More HERVs http://www.iayork.com/MysteryRays/2008/05/07/more-hervs/ Meddling with things mankind is not meant to understand. Also, pictures of my kids Wed, 10 Mar 2010 22:23:14 +0000 http://wordpress.org/?v=2.9.2 hourly 1 By: Richard Jefferys http://www.iayork.com/MysteryRays/2008/05/07/more-hervs/comment-page-1/#comment-5121 Richard Jefferys Fri, 16 May 2008 23:58:25 +0000 http://www.iayork.com/MysteryRays/?p=141#comment-5121 "I think it might be very interesting to look at CTL responses to HCP5 proteins." Sounds like a good idea, you could maybe drop a note to David Goldstein who did the SNP work: http://www.genome.duke.edu/people/faculty/goldstein/ He stated at a conference (CROI) back in Feb that their in vitro studies did not suggest an antisense mechanism but he didn't mention looking at CTL and seemed to be defaulting back to some linkage with B*57 (I also initially assumed a B*57 effect, but recently realized I have absolutely no clue as what effect a SNP in HCP5 could have on B*57 - any insights in that regard would be much appreciated!) “I think it might be very interesting to look at CTL responses to HCP5 proteins.”

Sounds like a good idea, you could maybe drop a note to David Goldstein who did the SNP work:

http://www.genome.duke.edu/people/faculty/goldstein/

He stated at a conference (CROI) back in Feb that their in vitro studies did not suggest an antisense mechanism but he didn’t mention looking at CTL and seemed to be defaulting back to some linkage with B*57 (I also initially assumed a B*57 effect, but recently realized I have absolutely no clue as what effect a SNP in HCP5 could have on B*57 – any insights in that regard would be much appreciated!)

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