http://www.iayork.com/MysteryRays/2008/05/11/a-therapeutic-catalytic-antibody/ Meddling with things mankind is not meant to understand. Also, pictures of my kids Tue, 16 Mar 2010 13:17:34 -0400 http://wordpress.org/?v=2.9.2 hourly 1 http://www.iayork.com/MysteryRays/2008/05/11/a-therapeutic-catalytic-antibody/comment-page-1/#comment-28508 Ulcer Mon, 20 Jul 2009 11:10:18 +0000 http://www.iayork.com/MysteryRays/?p=143#comment-28508 Could you please suggest some more information about this antibiotic.... I feel it very interesting....I would rather be happy if you let me know the pros and cons of this antibiotic so that I could share it with my friends... Could you please suggest some more information about this antibiotic…. I feel it very interesting….I would rather be happy if you let me know the pros and cons of this antibiotic so that I could share it with my friends…

]]> http://www.iayork.com/MysteryRays/2008/05/11/a-therapeutic-catalytic-antibody/comment-page-1/#comment-22111 NH Water Treatment Fri, 24 Apr 2009 20:26:26 +0000 http://www.iayork.com/MysteryRays/?p=143#comment-22111 Do you know if there were any side affects of raising the acidity in the Mice's stomachs? Do you know if there were any side affects of raising the acidity in the Mice’s stomachs?

]]> http://www.iayork.com/MysteryRays/2008/05/11/a-therapeutic-catalytic-antibody/comment-page-1/#comment-4465 Michael Clarkson Mon, 12 May 2008 03:32:46 +0000 http://www.iayork.com/MysteryRays/?p=143#comment-4465 The real killer for catalytic antibodies has always been their inability to exclude water from the active site. However, protease activity can make use of water, and moreover the breaking of peptide bonds can be catalyzed by acid. It's not unreasonable to think that even a modest catalyst might succeed as a protease under the special conditions present in the stomach. That the antibody is in part dependent on the ambient conditions is consistent with the fact that only the light chain is necessary. Do the authors establish that this fragment is an enzyme at neutral pH? The real killer for catalytic antibodies has always been their inability to exclude water from the active site. However, protease activity can make use of water, and moreover the breaking of peptide bonds can be catalyzed by acid. It’s not unreasonable to think that even a modest catalyst might succeed as a protease under the special conditions present in the stomach. That the antibody is in part dependent on the ambient conditions is consistent with the fact that only the light chain is necessary. Do the authors establish that this fragment is an enzyme at neutral pH?

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