… it may be important to readdress the therapeutic management of different cancers, given the idea that chemotherapy should elicit an immune response.  …  it could be important to preserve the sentinel lymph node rather than remove it systematically for disease staging purposes. Indeed, the sentinel lymph node constitutes the privileged site of antigen priming, in which the presence of activated DCs (expressing DC-LAMP – a protein only expressed in mature DCs) constitutes a positive prognostic marker, at least in melanoma.

The anticancer immune response: indispensable for therapeutic success?
Laurence Zitvogel, Lionel Apetoh, Francois Ghiringhelli, Fabrice Andre, Antoine Tesniere and Guido Kroemer. J. Clin. Invest. 118(6): 1991-2001 (2008). doi:10.1172/JCI35180.