Our results suggest that some CD8 T cells induced by vaccination are more efficient than others at responding to a viral challenge. These findings have implications for future AIDS virus vaccine studies, which should consider the “fitness” of vaccine-induced T cells in order to generate robust responses in the face of virus exposure.

 
Limited Maintenance of Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8 T-Cell Receptor Clonotypes after Virus Challenge.   Miranda Z. Smith, Tedi E. Asher, Vanessa Venturi, Miles P. Davenport, Daniel C. Douek, David A. Price, and Stephen J. Kent. Journal of Virology, August 2008, p. 7357-7368, Vol. 82, No. 15 doi:10.1128/JVI.00607-08

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