Here’s another extraordinary movie, taken from:
A. A. Cohen, N. Geva-Zatorsky, E. Eden, M. Frenkel-Morgenstern, I. Issaeva, A. Sigal, R. Milo, C. Cohen-Saidon, Y. Liron, Z. Kam, L. Cohen, T. Danon, N. Perzov, U. Alon (2008). Dynamic Proteomics of Individual Cancer Cells in Response to a Drug Science DOI: 10.1126/science.1160165
This shows cancer cells responding to a drug used in chemotherapy (camptothecin). The drug kills many, though not all, of the cells; the paper is aimed at finding correlates between various cellular proteins, and the cells’ ability to survive. But the move here can be interpreted more simply. We see the cancer cells, untreated for 24 hours, rapidly dividing and squirming around. (There are lots of clear examples of cells dividing; for example, a little bit toward 7:00 from center, at 5 hours; and just below center, at 19 hours.). At 24 hours, the drug is added; within another 12 hours, the cells slow down, and around 48 hours we see them starting to die (dead and dying cells are helpfully boxed).
In other news, I’ll be at the Autumn Immunology Conference in Chicago this weekend. Should be good.
[…] which allow me easy access to a wealth of media (a.k.a distractions) from awesome experimental data to cultural gems like […]
[…] Pubblicato da cirillod su Dicembre 17, 2008 Watch them die […]
I keep watching that over and over. Absolutely fascinating to see. Even though it takes 12 hours for the cells to slow noticeably, it seems like it acts to prevent mitosis even quicker. The last cell split I can spot is around the 27 hour mark.
This might shed more light on the secrets of longer life (via repairing these cells if there is a way to apply this knowledge to cellular repair at the microscopic level). Interesting video.
[…] they may detect damage to their DNA (as in cancer); or they may have detected viral infection. (See here, where I posted a movie of cells undergoing programmed […]