Saleh et al Fig 3

It was previously thought that Drosophila is unable to spread systemically an RNAi response, based on observations that endogenously expressed RNA hairpins do not spread from cell to cell. However, we demonstrate that, upon virus infection, infected cells spread systemically a silencing signal that elicits protective RNAi-dependent immunity throughout the organism. … In striking parallel to vertebrates, flies also rely on systemic immunity, albeit in this case the virus-specific signal is dsRNA-based. 1


  1. Saleh, M., Tassetto, M., van Rij, R., Goic, B., Gausson, V., Berry, B., Jacquier, C., Antoniewski, C., & Andino, R. (2009). Antiviral immunity in Drosophila requires systemic RNA interference spread Nature, 458 (7236), 346-350 DOI: 10.1038/nature07712[]