Malaria life cycle
Life cycle of Plasmodium falciparum

“In this article we have attempted to make the case that we may not know enough about malaria to make an effective vaccine. If we agree that the development of a malaria vaccine would profit from a better understanding of the basic immunology of the human response to malaria, we then need to ask the following question: have we engaged a sufficient number of immunologists to address the problem? At the moment, probably not. Relative to the magnitude of the global disease burden imposed by malaria, there are only a small number of scientists with the training and expertise in the human immune system who are committed to working at the molecular interface of the parasite and the immune system.”

Pierce, S., & Miller, L. (2009). World Malaria Day 2009: What Malaria Knows about the Immune System That Immunologists Still Do Not The Journal of Immunology, 182 (9), 5171-5177 DOI: 10.4049/jimmunol.0804153