… the overall analysis emphasizes the naiveté of believing that researchers could look at the sequence of a single wild-type protein, predict—using bioinformatics—its capacity to bind one or several common HLA molecules, and know with assurance exactly which protein sequence to incorporate into a favorite immunogenic vector.

–Margulies DH (2009) Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution. Nat Immunol 10:566–568. doi:10.1038/ni0609-566

(referring to
Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, Lamberth K, Chang CH, Harndahl M, Weimershaus M, Gerstoft J et al. (2009) Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance. Nat Immunol 10:636–646. doi:10.1038/ni.1728 )