Thus, not unlike the solutions to global warming or dependence on foreign oil, the proper immunization for rapidly evolving viruses cannot be a single T cell vaccine but instead must combine many different modalities that, like the ‘cooperative arms’ of the immune system, work in a complementary way to counter several steps of a pathogen’s life cycle.

–Margulies DH (2009) Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution. Nat Immunol 10:566–568. doi:10.1038/ni0609-566

(referring to
Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, Lamberth K, Chang CH, Harndahl M, Weimershaus M, Gerstoft J et al. (2009) Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance. Nat Immunol 10:636–646. doi:10.1038/ni.1728 )