Comments on: MHC vs pathogens: Evolution showdown http://www.iayork.com/MysteryRays/2010/10/07/mhc-vs-pathogens-evolution-showdown/ Meddling with things mankind is not meant to understand. Also, pictures of my kids Tue, 14 May 2013 16:59:33 +0000 hourly 1 http://wordpress.org/?v=3.5.1 By: MHC vs pathogens: Evolution showdown | Science Report | Biology News, Economics News, Computer Science News, Mathematics News, Physics News, Psychology News http://www.iayork.com/MysteryRays/2010/10/07/mhc-vs-pathogens-evolution-showdown/comment-page-1/#comment-63820 MHC vs pathogens: Evolution showdown | Science Report | Biology News, Economics News, Computer Science News, Mathematics News, Physics News, Psychology News Thu, 07 Oct 2010 15:53:25 +0000 http://www.iayork.com/MysteryRays/?p=2689#comment-63820 [...] the reason there are so many MHC alleles is related to their ability to protect against pathogens.1 The version is probably the frequency-dependent selection model. According to this, pathogens are [...]

]]> By: albatross http://www.iayork.com/MysteryRays/2010/10/07/mhc-vs-pathogens-evolution-showdown/comment-page-1/#comment-63798 albatross Thu, 07 Oct 2010 14:16:33 +0000 http://www.iayork.com/MysteryRays/?p=2689#comment-63798 Are there other effects of MHC on fitness, in terms of stuff like different likelihood of autoimmune disease?

You’ve said before that MHC genes tend to be one of the most diverse bits of the genome for most animals. Is there some evolved-in mechanism for maximizing that diversity by making those genes mutate more in the germline? (As opposed to the interesting sexual selection stuff?)

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