Then, it would seem to have been all but unanimous; and now, one would think, at first sight, that it were almost an insult to human understanding to be obliged to collect statistics to prove that vaccination confers a large exemption from attacks of small pox, and almost absolute security against death from that disease. … The general ignorance of the community, especially of the lower orders, as to the aim and object of vaccination, is lamentably great, and has still to be overcome.
The Science and Practice of Medicine, Vol. I (Second edition)
Charles Griffin and Company, London, 1863