Ian's publications

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Peer-reviewed publications:

Towne, C.F., I.A. York, L.B. Watkin, J.S. Lazo, and K.L. Rock.
Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses.
Journal of Immunology (2007) 178:6923-30

York, I.A., N. Bhutani, S. Zendzian, A.L. Goldberg, and K.L. Rock.
Tripeptidyl peptidase II (TPPII) is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.
Journal of Immunology (2006) 177:1434-1443

York, I.A., M.A. Brehm, S. Zendzian, C.F. Towne, and K.L. Rock.
ER-Aminopeptidase I (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in establishing immunodominance.
Proc. Natl. Acad. Sci. USA (2006) 103:9202-9207

Towne, C.F., I.A. York, J. Neijssen, M.L. Karow, A.J. Murphy, D.M. Valenzuela, G.D. Yancopoulos, J.J. Neefjes, and K.L. Rock.
Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation.
Journal of Immunology (2005) 175:6605-6614

York, I.A., E.P. Grant, A.M. Dahl, and K.L. Rock.
A mutant cell with a novel defect in MHC class I quality control.
Journal of Immunology (2005) 174:6839-6846

York, I.A., A.X. Mo, K. Lemerise, W. Zeng, Y. Shen, C.R. Abraham, T. Saric, A.L. Goldberg, and K.L. Rock.
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.
Immunity. (2003) 18:429-40.

York, I.A., S.-C. Chang, T. Saric, J.A. Keys, J.M. Favreau, A.L. Goldberg, and K.L. Rock.
The ER aminopeptidase, ERAP1, enhances or limits antigen presentation by trimming epitopes to 8-9 residues.
Nature Immunology (2002) 3:1177-1184

Saric, T., S.-C. Chang, A. Hattori, I.A. York, S. Markant, K.L. Rock, M. Tsujimoto, and A.L. Goldberg.
ERAP1, an interferon-induced aminopeptidase in the endoplasmic reticulum, that trims precursors to MHC class I-presented peptides.
Nature Immunology (2002) 3:1169-1176

Russell, H.I., I.A. York, K.L. Rock, and J.J. Monaco.
Class II antigen processing defects in two H2d mouse cell lines are caused by point mutations in the H2-DMa gene.
Eur. J. Immunol. (1999) 29:905-911

Tomazin, R., A. Hill, P. Jugovic, I. York, P. van Endert, H. Ploegh, D. Andrews, and D. Johnson.
Stable binding of the herpes virus ICP47 protein to the peptide binding domain of TAP.
EMBO Journal (1996) 15:3256-3266

Hill, A., P. Jugovic, I. York, G. Russ, J. Bennink, J. Yewdell, H. Ploegh, and D. Johnson.
Herpes simplex virus turns off the TAP to evade host immunity.
Nature (1995) 375:411-415

Levatte, M.A., L.C. Weaver, J.R. Smiley, I.A. York, D.C. Johnson, and G.A. Dekaban.
Delivery of a foreign gene to sympathetic preganglionic neurons using recombinant herpes simplex virus.
Neuroscience (1995) 66:737-750

York, I.A., C. Roop, D.W. Andrews, S.R. Riddell, F.L. Graham, and D.C. Johnson.
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.
Cell (1994) 77:525-535

York, I.A., and D.C. Johnson.
Direct contact with herpes simplex virus-infected cells results in inhibition of lymphokine-activated killer cells because of cell-to-cell spread of virus.
Journal of Infectious Diseases (1993) 168:1127-1131

York, I.A., and J. Thorsen.
Evaluation of a subunit vaccine for bovine adenovirus serotype 3.
American Journal Veterinary Research (1992) 53:180-183

Invited Reviews:

K.L. Rock, I.A. York, and A.L. Goldberg.
Post-proteasomal antigen processing for MHC class I presentation.
Nature Immunology (2004) 5:670-677

Rock, K.L., I.A. York, T. Saric, and A.L. Goldberg.
Protein degradation and the generation of MHC class I-presented peptides.
Advances in Immunology (2002) 80:1-70

York, I.A., A.L. Goldberg, X.Y. Mo, and K.L. Rock.
Proteolysis and class I major histocompatibility complex antigen presentation.
Immunological Reviews (1999) 172:49-66

York, I.A.
Immune evasion strategies of the herpesviruses.
Chemistry & Biology (1996) 3:331-335

York, I.A., and K.L. Rock.
Antigen processing and presentation by class I MHC.
Annual Review of Immunology (1996) 14:369-396

York, I.A., and D.C. Johnson.
Inhibition of humoral and cellular immune recognition by herpes simplex viruses.
IN: Viroceptors, Virokines, and Related Immune Modulators Encoded by DNA Viruses. Ed. G. McFadden. Austin: R.G. Landes Co., 1995:89-110

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